Taner @HTanerTeker

"young zebrafish🐟 have a functional BBB in the absence of (pdgfrb+) mural cells" Barrier permeability vs Focal leakage/hemorrhage A critical conceptual distinction😎 Cool evidence from pdgfrb mutant 10/70 kD dextran🤠 @ofbebaltaci @BenjaminHogan13 @eLife 2026 elifesciences.org/articles/104061

Tissue-resident macrophages acquire distinct identities shaped by local signals. @MRicoteLab et al. show that RXRs drive alveolar macrophage differentiation by regulating chromatin & gene expression in cooperation w other regulatory elements (1/2) hubs.la/Q04jQF6R0

By encapsulating an engineered CRISPR-Cas12 therapeutic in a phage therapy delivery system, a team designs a precision antimicrobial therapy for Shiga toxin-producing #Ecoli that cleaves the Stx gene and combats infection in animals. @ScienceTM scim.ag/4f8ivj4

Milk extracellular vesicles attenuate pre-inflammatory bowel disease via Lctobacillus murinus-mediated TLR2 signaling modulation dlvr.it/TSrGcL

Short RNAs may prevent neuron death linked to ALS, dementia: nih.gov/news-events/ni…

Findings support a metabolite-centered framework in which diet–microbiota interactions influence blood pressure regulation. Targeting gut microbiota through nutritional & microbiome-based strategies represents a promising adjunctive approach for hypertension prevention.

Mesenchymal drift: A convergent framework for the hallmarks of aging: Cell cell.com/cell/fulltext/…

Transposable elements are driving rapid adaptation of Enterococcus faecium | Nature nature.com/articles/s4158…

The link between gum disease and diabetes* … (Gum disease bacteria leak out of gums and spread throughout the body via the bloodstream, including to the liver.) (*other mechanisms involving gum disease bacteria in diabetes are available) 👇👇👇 doi.org/10.1016/j.bbad…

A wearable non-invasive sonogenetic pacemaker go.nature.com/4fU9fPM

Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators | Science science.org/doi/10.1126/sc…

Glucagon-like peptide-1 medicines and cancer | Nature Cancer nature.com/articles/s4301…

Investigating fasting for metabolic health and longevity 🤔"Here we present our perspective of the current rationale and evidence base to support fasting for gain in metabolic health. In the absence of individual level risk factors for potential harm, such as frailty, osteoporosis or osteopenia, or a current/historical eating disorder, a trial of intermittent fasting or time-restricted eating to promote weight loss and metabolic health is reasonable for the motivated patient who is overweight or obese We conclude, however, that the current state of evidence is limited and not sufficient to justify widespread adoption of fasting practices, nor is it sufficient to exclude the possibility that fasting holds a key to a longer life. We provide a template for the types of studies that will be required to optimize fasting protocols and establish therapeutic proof of concept. In our opinion, incorporation of mechanistic and multi-omics endpoints will be critical to understand potential mechanisms of benefit in humans; pathways that could ultimately be targeted with a fasting mimetic drug to obviate the need for long-term adherence to onerous dietary restriction." link.springer.com/article/10.100…

The Importance of Resistance Exercise Training to Combat Neuromuscular Aging ✅️ Progressive resistance training (RT) is the most effective and widely recommended strategy to combat sarcopenia (age-related loss of muscle mass and function) and physical limitations in older adults journals.physiology.org/doi/full/10.11… @HealthyFellow @tatiann69922625 @Mangan150 The neuromuscular benefits for older adults undergoing resistance exercise training (RT) extend beyond muscle mass and strength.

Louisa Nicola @louisanicola_

2 days ago

Source: journals.physiology.org/doi/full/10.11…

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Health effects associated w/alcohol consumption: a Burden of Proof study ▶️ Levels of current alcohol consumption are associated w/increased risks for cancers of the breast, colorectum, oesophagus, larynx, lip & oral cavities, pharynx, liver, stomach, pancreas & prostate, as well as pancreatitis, cirrhosis & other chronic liver diseases, lower respiratory infections, tuberculosis, & atrial fibrillation & flutter. ▶️ It was found J- or U-shaped relationships between alcohol consumption & type 2 diabetes, Alzheimer’s disease & other dementias, ischaemic heart disease, ischaemic stroke & haemorrhagic stroke. nature.com/articles/s4436… Risk–outcome-specific risk curves and funnel plots. a, Alcohol consumption & other pharyngeal cancer. b, Alcohol consumption & cirrhosis & other chronic liver diseases. c, Alcohol consumption & type 2 diabetes. d, Alcohol consumption & oesophageal cancer. e, Alcohol consumption & ischaemic heart disease.

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study) - Wang - 2025 - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/full/10.10…

Out now in Science! Our new study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵 science.org/doi/10.1126/sc…

Online Now: Ribo-Tweezer: Rapid removal of ribosomal proteins reveals additional layers of post-transcriptional gene regulation dlvr.it/TSfgdY

Universal transcriptomic hallmarks of mammalian ageing and mortality | Nature nature.com/articles/s4158…

In a paper just published in @ScienceMagazine, we teamed up with @teichlab to construct the most detailed atlas to date of hormone production and action in humans at cellular resolution. (1/8) Link: science.org/doi/10.1126/sc…