Klevit Lab @KlevitLab
@UWBiochemistry. Ubiquitin and small heat-shock proteins. Biochemistry and biophysics. Student-run account. Email Rachel with inquiries. klevitlab.org Seattle, WA Joined August 2021-
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Following108
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Klevit Lab retweeted
Really happy to share our paper out today @ Molecular Cell, where we elucidate the pivotal roles of BRCA1-BARD1 ligase in not only early DNA end resection but also subsequent stages in homology-directed repair. Congratulations to all the authors! sciencedirect.com/science/articl…
Grad School Updates: Natalie Stone pursues a PhD at University of Washington - #gradschool #research wix.to/RuDOs68
Grad School Updates! #gradschool #research wix.to/ArJDgdW
Grad School Updates! #gradschool #research wix.to/Zn6v5XP
The final version of our work highlighting the role of BARD1 in BRCA1/BARD1-mediated chromatin recognition and modification is out now @embojournal
Klevit Lab retweeted
I'm a bit behind on posting this (as I just finished moving transatlantic) but my second PhD paper is finally published! @NatureComms nature.com/articles/s4146…
Klevit Lab retweeted
The Preview ‘HHARI in motion reveals an unexpected substrate recognition site for RBR ligases’ from Ben Stieglitz @QMUL doi.org/10.1016/j.str.… highlights the recent Structure paper from @KlevitLab @UWBiochemistry: doi.org/10.1016/j.str.…
Klevit Lab retweeted
Super excited for Chris Woods to defend his dissertation (working with @KlevitLab) gonna be 🔥🔥
A wonderful collaborative effort with the labs of Mike Guttman, Trisha Davis, and Mike MacCoss.
HDX-MS, XL-MS, and NMR studies reveal that HHARI is released from auto-inhibition by a phosphomimetic mutation, and that the Rcat domain contains a substrate-binding surface.
We are thrilled to share our work on Cullin-independent substrate recognition by the RBR E3 ligase HHARI, led by @KHReiter now out in @Structure_CP. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic. authors.elsevier.com/a/1fG9j3SNvc2z…
Klevit Lab retweeted
There is a story that I have been wanting to tell for a while regarding a scientific journey that started more than 6 years ago. It’s been a really eye-opening process and I hope it can serve as an inspiration to others, especially those starting their research careers. A 🧵...
Klevit Lab retweeted
Really excited (and a little jealous) that @tylergfranklin is spending the week up in the @KlevitLab at @UWBiochemistry. Can’t wait to see what kind of data he comes home with. I wonder if my old lab bench is available…
Klevit Lab retweeted
I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. biorxiv.org/content/10.110…
Exciting new preprint from past lab member @HannahEBaughman
We posted a manuscript of my postdoc research on bioRxiv yesterday. We characterize the transcription activation domain of RelA and found that it enhances the binding affinity of the p50/RelA heterodimer for DNA, especially for sequences that don't match the κB consensus motif.
Klevit Lab retweeted
1/4 Join us at this year's @FASEBorg summer conference "The Ubiquitin and Ub-like Proteins Conference: Cell Functions and Therapeutic Targeting" July 24-28 in Southbridge, MA. faseb.org/meetings-and-e…
We're looking for a post-doc to join our BRCA1/BARD1 team. Lots of exciting science to be done. Contact Rachel @ [email protected].
Check out our new review highlighting recent structural and cellular insights into BRCA1/BARD1 recognition and activity at nucleosomes!
We posted a manuscript of my postdoc research on bioRxiv yesterday. We characterize the transcription activation domain of RelA and found that it enhances the binding affinity of the p50/RelA heterodimer for DNA, especially for sequences that don't match the κB consensus motif.
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