The Ward Lab @WardLab1
A structural bio lab using electron microscopes to study HIV, Ebola, Flu, Malaria, Coronaviruses, and membrane proteins. Views are our own. ward.scripps.edu San Diego Joined June 2018-
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Congratulations to new @NSF #GRFP fellows: Gabrielle in the @MGClab, Jared in the lab of Luke Lairson, @alexxsaladbar in the @LanderLab, Leigh in the @WardLab1 and Noah in the @disney_lab!
Holding it together: Nanoparticle stabilization of LASV trimer. @bmgunn31 examines work of @AA_Lab_EPFL @WardLab1 using two-component nanoparticle strategy that enables stable trimeric presentation of #Lassavirus glycoprotein complex & induction of bnAbs cell.com/cell-host-micr…
Featured Article: Lassa GPC nanoparticles- path to a vaccine? Stabilized #Lassa virus glycoprotein nanoparticle vaccine induces potent #antibody responses in rabbits & protects guinea pigs from #Lassavirus challenge @WardLab1 @AA_Lab_EPFL Brouwer & Sanders cell.com/cell-host-micr…
Incredible work from Philip, @AA_Lab_EPFL, Rogier Sanders (@amsterdamumc) and more! Officially out in @cellhostmicrobe. We describe the presentation of Lassa GPC on nanoparticles and show it can induce neutralizing responses at a novel epitope. Full story: cell.com/cell-host-micr…
New in Science: Researchers have determined the cryo–electron microscopy structure of the hepatitis C virus E1E2 glycoprotein complex. The structure provides a blueprint for the design of vaccines and drugs that target the virus. scim.ag/jP
A new endowed fund set up by Prof. Andrew Ward is helping up-and-coming scientists from under-represented backgrounds to enroll in university without the worries of financial insecurity. Congratulations to inaugural recipient Alesandra Rodriguez magazine.scripps.edu/profiles/2022/… @WardLab1
Another malaria CSP antibody story describing the structural basis of how unique homotypic interactions in the L9 antibody result in a potent and protective phenotype! #malaria #cryoEM. Now available in BioRxiv biorxiv.org/content/10.110…
Two studies from Prof. Bill Schief’s lab & collaborators describe an approach to design a custom HIV vaccine that can coax the immune system to produce the right broadly neutralizing antibodies in a stepwise manner scripps.edu/news-and-event… @ImmunityCP @ragoninstitute @moderna_tx
And here's a short video what we're doing for a universal, variant-proof Covid vaccine, via joint efforts of immunology and structural biology, with @DennisRBurton and Ian Wilson, @WardLab1 youtube.com/watch?v=O2d8jG…
Great talk from Julianne and work from Team Flu!
Beautiful analysis of maturation and cross-reactivity of antibody responses following flu vaccination by @julianna_han @OptionsXi @WardLab1 Specificity lost to cross-reactivity and mapping of how HA escapes. Bonus points for having to work with @TheBcellArtist (my sympathies)
Outstanding work from @HaileePerrett and Philip Brouwer, go check out the paper and the beautiful Lassa GPC figures. Congrats to all involved!
Really excited to finally share our work on #Lassa's fusion glycoprotein (GPC) on bioRxiv! We explore GPC structures across lineages, antibodies targeting the apex of the trimer (which impede receptor binding), and describe a new NAb! Read more here!🔬 biorxiv.org/content/10.110…
Beautiful work done by our Post Doc Gregory Martin and team including Jon Torres, Grace Gibson, Wilma Lee, Jeffrey Copps. 😍 #thatcryotho #malaria #cryoEM
Very cool #cryoEM reconstructions from @WardLab1! These #malaria Fabs are so cute ☺️ “Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection” | #bioRxiv biorxiv.org/content/10.110…
Many scientists are working toward the gold standard of infectious disease prevention: universal vaccines. But what does that mean? A quick intro! (& as always, a huge shoutout to Matt, Faith, and Drew—teamwork makes the dream work!) @scrippsresearch youtube.com/watch?v=1ROgFu…
Keep an eye out for cool science coming from the Murin lab!
Please welcome the Murin Lab @scrippsresearch! We are grateful to currently be housed by @WardLab1 and collaborating with them. From left to right: @daniel_murin (PI), Kayla Xu (summer intern) and Ryan Lin (Technician). Our website will be up soon! murinlab.com
So proud of you @HaileePerrett! Keep up the great work. We are lucky to have you.
Kicking off the start of year 4 of grad school with the official NoA for my NIAID F31. 🎉 Feeling deeply grateful for the support of so many lovely scientists, funding agencies, and donors over the years. The adventure continues!
Including lots of work from our lab members Wilma Lee and Jon Torres. nsEM getting the job done!
The @andrabi_raiees, @DennisRBurton, and Wilson labs find macaques produce broadly neutralizing, variant-protective antibodies after #SARSCoV2 vaccination – providing insights to guide the design and testing of future #COVID19 vaccines. @scrippsresearch fcld.ly/val5q0x
Well done Alba and colleagues! @albatorrents @scrippsresearch
New publication is out! @ragoninstitute @VirologyHarvard @harvardmed sciencedirect.com/science/articl…
Many months & edits later, our work on the baseline SARS-CoV-2 spike-reactive B cell repertoire is (finally!) out in @NatureComms. ⬇ Most interesting & relevant results below. It gets cool. ⬇ @vanGilsLab nature.com/articles/s4146… (1)
With the help of the very talented @julianna_han @WardLab1, we found out that this IGHV1-69/IGKV3-11 B cell pairing exclusively targets an apical S2 domain, which is normally obscured on the prefusion spike trimer but might be present in open and/or aberrant conformations. (8)
Trying something new for our lab outing! #watchout #axethrowing #badaxe
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